Understanding immune senescence to improve vaccine responses
By J. Goronzy, C. Weyand. Nature Immunology, 2013
734 citations recorded by the source corpus.
In the older adult, the benefits of vaccination to prevent infectious disease are limited, mainly because of the adaptive immune system's inability to generate protective immunity. The age-dependent decrease in immunological competence, often referred to as 'immunosenescence', results from the progressive deterioration of innate and adaptive immune responses. Most insights into mechanisms of immunological aging have been derived from studies of mouse models. In this Review, we explore how well such models are applicable to understanding the aging process throughout the 80–100 years of human life and discuss recent advances in identifying and characterizing the mechanisms that underlie age-associated defective adaptive immunity in humans.
Subfields: Immunology, Molecular Biology, Neurology
View Paper: https://www.semanticscholar.org/paper/efe2bdd5f0b394b272a4a03e9460a5a549c2bd4c
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Citations in the corpus
- Hyperprogressive Disease Is a New Pattern of Progression in Cancer Patients Treated by Anti-PD-1/PD-L1 (2016, background): “This may be explained by a different immunological background in older patients such as modification of T-cell costimulatory/co-inhibitory proteins expression or higher concentrations of inflammatory cytokines (20, 21).”
- Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention (2019, methodology): “Therefore, these hallmarks of immunosenescence would be markedly affected by the history of the individual exposure to pathogens (6, 23).”
- Resistance Mechanisms to Immune-Checkpoint Blockade in Cancer: Tumor-Intrinsic and -Extrinsic Factors. (2016, neutral): “For example, segmented filamentous bacteria (SFB) are potent inducers of Th17 and Th1 cells in the small intestine (Goto et al., 2014; Ivanov et al., 2009).”