Transfer of mitochondria from astrocytes to neurons after stroke
By K. Hayakawa, E. Esposito, Xiaohua Wang, Y. Terasaki, Yi Liu, Changhong Xing, X. Ji, Eng H. Lo. Nature, 2016
1,282 citations recorded by the source corpus.
Neurons can release damaged mitochondria and transfer them to astrocytes for disposal and recycling. This ability to exchange mitochondria may represent a potential mode of cell-to-cell signalling in the central nervous system. Here we show that astrocytes in mice can also release functional mitochondria that enter neurons. Astrocytic release of extracellular mitochondrial particles was mediated by a calcium-dependent mechanism involving CD38 and cyclic ADP ribose signalling. Transient focal cerebral ischaemia in mice induced entry of astrocytic mitochondria into adjacent neurons, and this entry amplified cell survival signals. Suppression of CD38 signalling by short interfering RNA reduced extracellular mitochondria transfer and worsened neurological outcomes. These findings suggest a new mitochondrial mechanism of neuroglial crosstalk that may contribute to endogenous neuroprotective and neurorecovery mechanisms after stroke.
Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience, Neurology
View Paper: https://www.semanticscholar.org/paper/efd1f2408fce524948e9aca055dd1a318774112f
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Citations in the corpus
- Packaging and transfer of mitochondrial DNA via exosomes regulate escape from dormancy in hormonal therapy-resistant breast cancer (2017, positive): “Additionally, it was recently shown that astrocytes and mesenchymal stem cells could release mitochondrial particles in microvesicles, which were taken up by damaged neurons or macrophages, enhancing their survival or OXPHOS activity (47, 48).”
- AI in Medical Imaging Informatics: Current Challenges and Future Directions (2020, neutral): “use in neuro [34], [33] and cancer [35] imaging among other areas.”
- Mitochondrial DNA in inflammation and immunity (2020, positive): “More recent work has shown that following stroke, whole mitochondria can be transferred from astrocytes to neurons, a process proven to be beneficial to recovery [196].”
- Mitochondrial dysfunction: mechanisms and advances in therapy (2024, background): “43,372 To shorten the preparation time, McCully, J. D. et al. proposed a tissue pool to obtain fresh mitochondria, including pectoralis major muscle, rectus abdominis or even sternocleido-mastoid muscle.”