A Single-Atom Nanozyme for Wound Disinfection Applications.
By Bolong Xu, Hui Wang, Weiwei Wang, Lizeng Gao, Shanshan Li, Xueting Pan, Hongyu Wang, Hailong Yang, Xiangqin Meng, Qiuwen Wu and 6 more. Angewandte Chemie, 2019
700 citations recorded by the source corpus.
Single-atom catalysts (SACs), as homogeneous catalysts, have been widely explored for chemical catalysis. However, few studies focus on the applications of SACs in enzymatic catalysis. Herein, we report that a zinc-based zeolitic-imidazolate-framework (ZIF-8)-derived carbon nanomaterial containing atomically dispersed zinc atoms can serve as a highly efficient single-atom peroxidase mimic. To reveal its structure-activity relationship, the structural evolution of the single-atom nanozyme (SAzyme) was systematically investigated. Furthermore, the coordinatively unsaturated active zinc sites and catalytic mechanism of the SAzyme are disclosed using density functional theory (DFT) calculations. The SAzyme, with high therapeutic effect and biosafety, shows great promises for wound antibacterial applications.
Subfields: Biomedical Engineering, Materials Chemistry, Renewable Energy, Sustainability and the Environment
View Paper: https://www.semanticscholar.org/paper/efa53eb33887736a995c4ea03f79b138d0a8ad8b
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Citations in the corpus
- Coordination Number Regulation of Molybdenum Single-Atom Nanozyme Peroxidase-like Specificity (2020, background): “In this regard, Yan and co-workers had constructed effective single-atom nanozymes with atomically dispersed Zn–N4 active sites as peroxidase mimics for antibacterial application for wounds.(21) Fe–N–C SACs with heme-like moieties were also created showing strong POD-mimicking activity.”