Microbial status of apical root canal system of human mandibular first molars with primary apical periodontitis after "one-visit" endodontic treatment.

By P. Nair, Stéphane Henry, V. Caño, J. Vera. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics, 2005

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Outcome of primary root canal treatment: systematic review of the literature -- Part 2. Influence of clinical factors. (2007, background): “It is likely that the infection in the apical anatomy would be better correlated to treatment outcome (Goria et al. 2005, Nair et al. 2005).”
On the causes of persistent apical periodontitis: a review. (2006, neutral): “…treatment and probably the major cause of persistent apical periodontitis, the cher-ished goal of endodontic treatment has been to eliminate infectious agents or to substantially reduce the microbial load from the root canal and to prevent re-infection by root ﬁlling (Nair 2004, Nair et al. 2005).”
Outcome of secondary root canal treatment: a systematic review of the literature. (2007, background): “This finding contradicts the commonly held belief (Selden 1974, Pekruhn 1986, Sjögren et al. 1990, Friedman et al. 1995) that 1 RCT is associated with better outcome than 2 RCT due to the difference in the nature (Gulabivala 2004) and location of root canal infection (Nair et al. 2005).”
A prospective study of the factors affecting outcomes of nonsurgical root canal treatment: part 1: periapical health. (2011, background): “Finally, larger lesions may represent a more exaggerated host response that responds less readily to ecological shifts effected in the canal infection by the treatment protocols (Nair et al. 2005).”