A molecular mechanism for osmolyte-induced protein stability

By Timothy O. Street, D. W. Bolen, G. Rose. Proceedings of the National Academy of Sciences of the United States of America, 2006

636 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Industrial Production of the Cell Protectant Ectoine: Protection Mechanisms, Processes, and Products (2014, background): “[40] it can similarly be concluded that methyl groups on positively charged atoms increase hydrophobicity (reducing the fractional polar surface area) while at the same time maintaining solubility.”
Plant-growth-promoting rhizobacteria to improve crop growth in saline soils: a review (2014, background): “In addition to their wellstudied function as osmoprotectants, compatible solutes also have protein-stabilising properties that support the correct folding of polypeptides under denaturing conditions both in vitro and in vivo (Street et al. 2006).”
Cellular response to hyperosmotic stresses. (2007, background): “The benefit is that compatible organic osmolytes perturb less than do inorganic ions (325) because they stabilize proteins by interacting favorably with the protein backbone (282).”