Vital Rates from the Action of Mutation Accumulation

By K. Wachter, David Steinsaltz, Steven N. Evans. Journal of Population Ageing, 2008

1,238 citations recorded by the source corpus.

New models for evolutionary processes of mutation accumulation allow hypotheses about the age-specificity of mutational effects to be translated into predictions of heterogeneous population hazard functions. We apply these models to questions in the biodemography of longevity, including proposed explanations of Gompertz hazards and mortality plateaus.

Subfields: Aging, Demography, Health, Toxicology and Mutagenesis

View Paper: https://www.semanticscholar.org/paper/ef0662dfcb1c4748ac486325d4272b24defd72b4

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