Birth prevalence of congenital heart disease worldwide: a systematic review and meta-analysis.
By D. van der Linde, Elisabeth E. M. Konings, Maarten A Slager, M. Witsenburg, W. Helbing, J. Takkenberg, J. Roos‐Hesselink. Journal of the American College of Cardiology, 2011
3,200 citations recorded by the source corpus.
Congenital heart disease (CHD) accounts for nearly one-third of all major congenital anomalies. CHD birth prevalence worldwide and over time is suggested to vary; however, a complete overview is missing. This systematic review included 114 papers, comprising a total study population of 24,091,867 live births with CHD identified in 164,396 individuals. Birth prevalence of total CHD and the 8 most common subtypes were pooled in 5-year time periods since 1930 and in continent and income groups since 1970 using the inverse variance method. Reported total CHD birth prevalence increased substantially over time, from 0.6 per 1,000 live births (95% confidence interval [CI]: 0.4 to 0.8) in 1930 to 1934 to 9.1 per 1,000 live births (95% CI: 9.0 to 9.2) after 1995. Over the last 15 years, stabilization occurred, corresponding to 1.35 million newborns with CHD every year. Significant geographical differences were found. Asia reported the highest CHD birth prevalence, with 9.3 per 1,000 live births (95% CI: 8.9 to 9.7), with relatively more pulmonary outflow obstructions and fewer left ventricular outflow tract obstructions. Reported total CHD birth prevalence in Europe was significantly higher than in North America (8.2 per 1,000 live births [95% CI: 8.1 to 8.3] vs. 6.9 per 1,000 live births [95% CI: 6.7 to 7.1]; p < 0.001). Access to health care is still limited in many parts of the world, as are diagnostic facilities, probably accounting for differences in reported birth prevalence between high- and low-income countries. Observed differences may also be of genetic, environmental, socioeconomical, or ethnic origin, and there needs to be further investigation to tailor the management of this global health problem.
Subfields: Epidemiology, Pulmonary and Respiratory Medicine
View Paper: https://www.semanticscholar.org/paper/eec9582155df3ec3a1075bfe5cefd84c3796fcec
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Citations in the corpus
- Functional Knowledge Transfer for High-accuracy Prediction of Under-studied Biological Processes (2013, background): “Deviations in left-right heart development can lead to complex congenital heart defects that are among the most common human neonatal diseases [46,47].”
- Global birth prevalence of congenital heart defects 1970–2017: updated systematic review and meta-analysis of 260 studies (2019, methodology): “A systematic review of global prevalence data since 1930 was conducted by van der Linde et al.1 in 2010, suggesting an increase in CHD prevalence from the 1930s until 1995, with stabilization between the years 1995–2009.”
- 2015 ESC Guidelines for the management of patients with ventricular arrhythmias and the preventionof sudden cardiac death (2015, neutral): “CHD is the most common birth defect, with an incidence of 700–800 per 100 000 live births.(499) Patients with CHD represent”
- 2020 ESC Guidelines for the management of adult congenital heart disease (2021, background): “1 Prevalence of adult congenital heart disease To date, the prevalence of CHD worldwide is 9 per 1000 newborns, with substantial geographic variation.(2,3) While the prevalence of severe congenital heart defects is declining in many Western/ developed countries due to foetal screening and pregnancy ”