Dynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiation

By G. Ficz, Miguel R. Branco, Stefanie Seisenberger, Fátima Santos, Felix Krueger, T. Hore, C. Marques, Simon R. Andrews, Wolf Reik. Nature, 2011

1,157 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/eec202669dc1d351c17e37c7c6ead4a99da1dd2b

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In Molecular Biology

1. Yi Zhang
2. Hao Wu
3. Wolf Reik
4. W. Dean
5. Jörn Walter
6. Felix Krueger
7. Fátima Santos
8. Chuan He

Citations in the corpus

• DNA methylome analysis using short bisulfite sequencing data (2012, background): “This limitation does not apply to antibody-based techniques, which can be used to specifically enrich 5hmC 26–28 .”
• 5-hmC–mediated epigenetic dynamics during postnatal neurodevelopment and aging (2011, background): “Given the distinct genomic distributions that were recently reported for 5-hmC in ES cells and adult brai”
• Modification of enhancer chromatin: what, how and why? (2013, background): “…been detected in genomes of several cell types, including ESCs, where it positively correlates with gene activity and is found at promoters, gene bodies, and enhancers (Ficz et al., 2011; Pastor et al., 2011; Stroud et al., 2011; Szulwach et al., 2011; Valinluck et al., 2004; Wu and Zhang, 2010).”
• Mechanisms and functions of Tet protein-mediated 5-methylcytosine oxidation. (2011, background): “…repressed lineage-specific genes (Wu et al. 2011b), whereas a cohort of actively transcribed Tet1 target genes, including several pluripotency-related transcription factors (e.g., Nanog, Tcl1, and Esrrb), are found to be downregulated in the absence of Tet1 (Ficz et al. 2011; Wu et al. 2011b).”
• CpG islands and the regulation of transcription. (2011, neutral): “Compatible with this hypothesis, recent studies locate Tet1 preferentially at CGIs in mouse ES cells (Ficz et al. 2011; Wu et al. 2011a,b), and depletion of Tet1 results in increased CpG methylation at CGIs (Wu et al. 2011a).”
• Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation (2011, neutral): “This is particularly evident given recent studies suggesting a dynamic interplay between changes in TET1-mediared hydroxymethylation and other epigenetic marks in regulating gene expression (Ficz et al., 2011; Williams et al., 2011; Wu et al., 2011), and it is likely additional alterations in the ep”
• Transcriptional and Epigenetic Mechanisms of Addiction (2011, background): “A variant of DNA methylation, 5-hydroxycytosine methylation, also seems to be important in gene regulatio”
• DNA Methylation and Its Basic Function (2013, background): “Although a direct connection between the two has yet to been shown, Tet1 does indeed localize to CpG islands and its depletion results in an increase in methylation within those CpG islands in mouse embryonic stem cell studies (Ficz et al, 2011; Wu and Zhang, 2011).”
• The Dynamics of Genome-wide DNA Methylation Reprogramming in Mouse Primordial Germ Cells (2012, methodology): “J1 ESCs (129S4/SvJae) were grown on feeder cells under standard conditions as described previously (Ficz et al., 2011).”
• LOSS OF 5-HYDROXYMETHYLCYTOSINE IS AN EPIGENETIC HALLMARK OF MELANOMA (2012, result): “This is not surprising because we and others have shown complex roles of 5-hmC in gene transcription regulation in mouse ES cells (Ficz et al., 2011; Xu et al., 2011b).”