Chronic palmitate but not oleate exposure induces endoplasmic reticulum stress, which may contribute to INS-1 pancreatic beta-cell apoptosis.

By Elizabeth Karaskov, C. Scott, Liling Zhang, Tracy Teodoro, M. Ravazzola, A. Volchuk. Endocrinology, 2006

607 citations recorded by the source corpus.

Subfields: Cell Biology, Epidemiology, Surgery

View Paper: https://www.semanticscholar.org/paper/ee15ce180616c5c8eabc2440874964187269e0c0

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. A. K. Cardozo
2. M. Cnop
3. Decio L. Eizirik

In Epidemiology

1. Mitchell A. Lazar
2. M. Cnop
3. M. Qatanani
4. Decio L. Eizirik
5. Barry M. Popkin
6. Haiming Cao

In Surgery

1. M. Cnop
2. F. Ortis
3. Mitchell A. Lazar
4. M. Qatanani
5. Decio L. Eizirik

Citations in the corpus

• Mechanisms of obesity-associated insulin resistance: many choices on the menu. (2007, background): “Also, chronic elevation of FAs has been shown to induce ER stress (Karaskov et al. 2006).”
• Initiation and execution of lipotoxic ER stress in pancreatic β-cells (2008, methodology): “…have since extended these observations and demonstrated that palmitate, and to a lesser extent oleate, activates an ER stress response in the INS-1(E) and MIN6 β-cell lines (Cnop et al., 2007a; Karaskov et al., 2006; Laybutt et al., 2007), but whether this occurs in primary β-cells is unknown.”