Subchronic oral toxicity of silver nanoparticles
By Yong Soon Kim, M. Song, J. Park, K. Song, Hyeon Ryol Ryu, Y. Chung, H. Chang, J. H. Lee, K. Oh, B. Kelman and 2 more. Particle and Fibre Toxicology, 2010
602 citations recorded by the source corpus.
BackgroundThe antibacterial effect of silver nanoparticles has resulted in their extensive application in health, electronic, consumer, medicinal, pesticide, and home products; however, silver nanoparticles remain a controversial area of research with respect to their toxicity in biological and ecological systems.ResultsThis study tested the oral toxicity of silver nanoparticles (56 nm) over a period of 13 weeks (90 days) in F344 rats following Organization for Economic Cooperation and Development (OECD) test guideline 408 and Good Laboratory Practices (GLP). Five-week-old rats, weighing about 99 g for the males and 92 g for the females, were divided into four 4 groups (10 rats in each group): vehicle control, low-dose (30 mg/kg), middle-dose (125 mg/kg), and high-dose (500 mg/kg). After 90 days of exposure, clinical chemistry, hematology, histopathology, and silver distribution were studied. There was a significant decrease (P < 0.05) in the body weight of male rats after 4 weeks of exposure, although there were no significant changes in food or water consumption during the study period. Significant dose-dependent changes were found in alkaline phosphatase and cholesterol for the male and female rats, indicating that exposure to more than 125 mg/kg of silver nanoparticles may result in slight liver damage. Histopathologic examination revealed a higher incidence of bile-duct hyperplasia, with or without necrosis, fibrosis, and/or pigmentation, in treated animals. There was also a dose-dependent accumulation of silver in all tissues examined. A gender-related difference in the accumulation of silver was noted in the kidneys, with a twofold increase in female kidneys compared to male kidneys.ConclusionsThe target organ for the silver nanoparticles was found to be the liver in both the male and female rats. A NOAEL (no observable adverse effect level) of 30 mg/kg and LOAEL (lowest observable adverse effect level) of 125 mg/kg are suggested from the present study.
Subfields: Health, Toxicology and Mutagenesis, Immunology, Materials Chemistry
View Paper: https://www.semanticscholar.org/paper/edbdf8ce9faa45dfe8a8540f50fededf97c228a2
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In Health, Toxicology and Mutagenesis
In Materials Chemistry
Citations in the corpus
- Distribution, elimination, and toxicity of silver nanoparticles and silver ions in rats after 28-day oral exposure. (2012, methodology): “Silver was also distributed to the brain, which is in correspondencewithprevious reports aswell.(3,4,8,12,19,29) 31”
- Silver nanoparticles: mechanism of antimicrobial action, synthesis, medical applications, and toxicity effects (2012, background): “It was also found from histopathological studies that there was a higher incidence of bile duct hyperplasia, with or without necrosis, fibrosis, and pigmentation in the study animals [84].”