Distinct bone marrow blood vessels differentially regulate hematopoiesis

By T. Itkin, S. Gur-Cohen, J. Spencer, A. Schajnovitz, Saravana K. Ramasamy, Anjali P. Kusumbe, Guy Ledergor, Yookyung Jung, I. Milo, Michael G. Poulos and 10 more. Nature, 2016

643 citations recorded by the source corpus.

Bone marrow endothelial cells (BMECs) form a network of blood vessels that regulate both leukocyte trafficking and haematopoietic stem and progenitor cell (HSPC) maintenance. However, it is not clear how BMECs balance these dual roles, and whether these events occur at the same vascular site. We found that mammalian bone marrow stem cell maintenance and leukocyte trafficking are regulated by distinct blood vessel types with different permeability properties. Less permeable arterial blood vessels maintain haematopoietic stem cells in a low reactive oxygen species (ROS) state, whereas the more permeable sinusoids promote HSPC activation and are the exclusive site for immature and mature leukocyte trafficking to and from the bone marrow. A functional consequence of high permeability of blood vessels is that exposure to blood plasma increases bone marrow HSPC ROS levels, augmenting their migration and differentiation, while compromising their long-term repopulation and survival. These findings may have relevance for clinical haematopoietic stem cell transplantation and mobilization protocols.

Subfields: Hematology, Immunology

View Paper: https://www.semanticscholar.org/paper/ed906af432278426e1b697c72e1ede6d73956dd2

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

1. H. Augustin
2. G. Koh
3. Antonio Scialdone
4. C. Bocian
5. Lena Woelk
6. Anne-Marie Jank
7. H. Fan
8. A. Schürmann

Citations in the corpus

• Adipocyte Accumulation in the Bone Marrow during Obesity and Aging Impairs Stem Cell-Based Hematopoietic and Bone Regeneration (2017, background): “…these functionally distinct cell populations and a preferential association of perivascular multipotent and adipogenic cells to L type vessels, while the distribution of endosteal osteogenic cells resembles more closely localizations of H type endothelium (Itkin et al., 2016; Kusumbe et al., 2014).”
• Organotypic vasculature: From descriptive heterogeneity to functional pathophysiology (2017, background): “Less permeable arterial blood vessels maintain HSCs in a state with low reactive oxygen species, whereas the more permeable sinusoids promote HSC activation and serve as sites for immature and mature leukocyte trafficking to and from the bone marrow (141).”