Nonreplicating persistence of mycobacterium tuberculosis.

By L. G. Wayne, C. Sohaskey. Annual Review of Microbiology, 2001

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Transcriptional Adaptation of Mycobacterium tuberculosis within Macrophages (2003, background): “Surviving bacteria are believed to enter a period of nonreplicating persistence in the phagosome until waning host immunity leads to reactivation from the latent state and the onset of disease (8).”
Rv3133c/dosR is a transcription factor that mediates the hypoxic response of Mycobacterium tuberculosis (2003, background): “Oxygen tension is one factor frequently associated with the establishment and maintenance of latent TB (Wayne and Sohaskey, 2001).”
Inhibition of Respiration by Nitric Oxide Induces a Mycobacterium tuberculosis Dormancy Program (2003, background): “However, the predicted roles of some of the dormancy regulon genes appear to explain many of the previously reported biochemical or physiological properties of the low O2–induced dormant state (5).”
Tuberculous Granulomas Are Hypoxic in Guinea Pigs, Rabbits, and Nonhuman Primates (2008, background): “This concept underlies the in vitro models of hypoxiainduced nonreplicating persistence in which the growth of the organism is arrested by oxygen depletion (44).”