Regional specialization within the intestinal immune system

By A. Mowat, W. Agace. Nature reviews. Immunology, 2014

1,582 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/3fbcc4713c1bb74d76d0090175d7a6a194b256ec

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Citations in the corpus

Butyrate: A Double-Edged Sword for Health? (2018, background): “Several human and animal studies reported that the proinflammatory cytokines IFN-γ , TNFα, IL-1β , IL-6, and IL-8 are inhibited, whereas IL-10 and TGF-β are upregulated in response to butyrate (25).”
Gut Microbiota and Immune System Interactions (2020, background): “Gut permeability is closely linked to both commensal microbiota and elements of the mucosal immune system, and is influenced by many factors including gut microbiota modifications, mucus layer alterations, and epithelial damage [46,47].”
Single-Cell Analysis of Crohn’s Disease Lesions Identifies a Pathogenic Cellular Module Associated with Resistance to Anti-TNF Therapy (2019, methodology): “populations related to local variations in the intestinal micro-organization (Mowat and Agace, 2014), we pooled fifteen to twenty mucosal biopsies sampled all along the resected specimens using a biopsy forceps (EndoChoice, Alpharetta, GA) to prepare cell suspensions.”
Post-COVID syndrome in non-hospitalised patients with COVID-19: a longitudinal prospective cohort study (2021, positive): “Since the intestine is the largest lymphatic organ [35], there may be a possible link between residual viral particles in the intestine and longterm symptoms.”
Fusobacterium nucleatum and T-cells in Colorectal Carcinoma (2015, neutral): “Q3 (24-48) 137 (25) 117 (24) 11 (34) 9 (24)”
Intestinal barrier and gut microbiota: Shaping our immune responses throughout life (2017, background): “The PP, more frequent in the ileum where bacterial load is greater, are important induction sites that contain all the immune-competent cells necessary to induce antigen-specific responses.(9) They also have a specialized follicle epithelium of microfold (M) cells, capable of sampling and transporti”
Human gut microbiome: hopes, threats and promises (2018, background): “20 Notably, the immune system also has a predominant effect on the composition of the microbiota.”