The primary mechanism of attenuation of bacillus Calmette–Guérin is a loss of secreted lytic function required for invasion of lung interstitial tissue
By Tsungda Hsu, S. Hingley-Wilson, Bing Chen, Mei Chen, Annie Z Dai, P. Morin, Carolyn B. Marks, Jeevan Padiyar, C. Goulding, M. Gingery and 8 more. Proceedings of the National Academy of Sciences of the United States of America, 2003
764 citations recorded by the source corpus.
Subfields: Epidemiology, Immunology, Infectious Diseases
View Paper: https://www.semanticscholar.org/paper/ed2af6975a92e15c99329ee901071a0fbd77b804
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Citations in the corpus
- Extracellular M. tuberculosis DNA Targets Bacteria for Autophagy by Activating the Host DNA-Sensing Pathway (2012, neutral): “Mounting evidence strongly suggests that ESAT-6, the major ESX-1-secreted substrate, has membrane-damaging activity (de Jonge et al., 2007; Hsu et al., 2003; Smith et al., 2008) that functions to permeabilize the phagosomal membrane, allowing access of the bacterium to the cytosol (Stamm et al.”
- Type VII secretion — mycobacteria show the way (2007, background): “However, recent studies have provided evidence that there is an alternative protein-secretion system in Gram-positive bacteri”
- M. tuberculosis and M. leprae translocate from the phagolysosome to the cytosol in myeloid cells. (2007, background): “The ESX-1 region has an important role in the virulence of M. tuberculosis (Lewis et al., 2003; Hsu et al., 2003; Stanley et al., 2003).”