Regulation of DNA double-strand break repair pathway choice

By M. Shrivastav, L. D. Haro, J. Nickoloff. Cell Research, 2008

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53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks (2010, neutral): “Our data are consistent with the idea that these two DSB repair pathways compete for repair of replication-associated chromatid breaks (Saberi et al., 2007; Shrivastav et al., 2008; Sonoda et al., 2006).”
Comparison of nonhomologous end joining and homologous recombination in human cells (2008, background): “Both DSB repair pathways play important roles in mammalian DSB repair [4,5].”
Enhanced homology-directed human genome engineering by controlled timing of CRISPR/Cas9 delivery (2014, background): “Although chemical or genetic interruption of the NHEJ pathway can favor HDR (Shrivastav et al., 2008), such manipulations can be difficult to employ, harmful to cells or both.”
The DNA Damage Response: Making it safe to play with knives (2010, background): “Interestingly, ABCDE phosphorylation, which can also be induced by ATM, has been shown to facilitate the access of DNA ends to DSB resecting enzymes in order to promote HR whenNHEJ fails (Shrivastav et al., 2008).”