Biofilm Matrixome: Extracellular Components in Structured Microbial Communities.
By L. Karygianni, Zhiyong Jason Ren, Hyun Koo, T. Thurnheer. Trends in Microbiology, 2020
1,201 citations recorded by the source corpus.
Biofilms consist of microbial communities embedded in a 3D extracellular matrix. The matrix is composed of a complex array of extracellular polymeric substances (EPS) that contribute to the unique attributes of biofilm lifestyle and virulence. This ensemble of chemically and functionally diverse biomolecules is termed the 'matrixome'. The composition and mechanisms of EPS matrix formation, and its role in biofilm biology, function, and microenvironment are being revealed. This perspective article highlights recent advances about the multifaceted role of the 'matrixome' in the development, physical-chemical properties, and virulence of biofilms. We emphasize that targeting biofilm-specific conditions such as the matrixome could lead to precise and effective antibiofilm approaches. We also discuss the limited knowledge in the context of polymicrobial biofilms, and the need for more in-depth analyses of the EPS matrix in mixed communities that are associated with many human infectious diseases.
Subfields: Ecology, Environmental Engineering, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/ec9d1de88607969efb0d503d4cd754ae89ea1483
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Citations in the corpus
- Candida albicans—The Virulence Factors and Clinical Manifestations of Infection (2021, background): “An essential part of the extracellular matrix are β-1,3-glucans, which significantly contribute to the biofilm’s resistance to antifungal drugs because they prevent contact with target cells [36].”