A lipidomic analysis of nonalcoholic fatty liver disease

By P. Puri, R. Baillie, Michelle M. Wiest, F. Mirshahi, J. Choudhury, Onpan Cheung, Carol Sargeant, M. Contos, A. Sanyal. Hepatology, 2007

1,300 citations recorded by the source corpus.

Subfields: Epidemiology, Nutrition and Dietetics, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/ec91597801c9515d0d600cfde253aebb042cf7f1

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. A. Sanyal
2. B. Neuschwander‐Tetri
3. E. Brunt
4. G. Svegliati-Baroni
5. R. Kaufman
6. F. Marra
7. Z. Younossi
8. M. Rinella

In Nutrition and Dietetics

1. Kate Schroder

In Pathology and Forensic Medicine

1. A. Sanyal
2. E. Brunt

Citations in the corpus

• NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice (2017, background): “We and others [42,44] have demonstrated that the predominant lipidomic abnormality in the MCD-fed mice is accumulation of saturated free fatty acids, differing from foz/foz mice and human NASH in which free cholesterol is the toxic lipid that distinguishes NASH from simple steatosis [30,38-41].”
• INCREASED HEPATIC SYNTHESIS AND DYSREGULATION OF CHOLESTEROL METABOLISM IS ASSOCIATED WITH THE SEVERITY OF NONALCOHOLIC FATTY LIVER DISEASE (2012, background): “Mean ± SD shown for all graphical data. unfolded protein response (Puri et al., 2007; Puri et al., 2008).”
• Hepatic lipotoxicity and the pathogenesis of nonalcoholic steatohepatitis: The central role of nontriglyceride fatty acid metabolites (2010, background): “Increases in DAG species have been suspected as a major contributor to hepatic lipotoxicity;(34,59) however, lipidomic analysis of liver biopsy specimens from patients with NAFLD with or without steatohepatitis found similar DAG levels, although both had higher levels than was found in normal liver.”
• Role of Dietary Fructose and Hepatic de novo Lipogenesis in Fatty Liver Disease (2016, background): “In states of insulin resistance such as obesity and NALFD, insulin continues to support DNL, while its capacity to reduce hepatic gluconeogenesis is impaired.”
• Endoplasmic Reticulum Stress in Liver Disease (2010, background): “Free fatty acid composition of triacylglycerol (TAG), the predominant lipid class, and diacylglycerol (DAG) in patients with NAFLD and NASH, demonstrated a trend for higher palmitic acid and oleic acid with a concomitant decrease in polyunsaturated fatty acids [109].”
• Lipotoxicity and the gut-liver axis in NASH pathogenesis. (2018, background): “Accordingly, decreased levels of n-3 PUFA have been found in patients with NASH [21] and supplementation with this lipid class as a therapeutic approach to”
• Nonalcoholic fatty liver disease: pathology and pathogenesis. (2010, background): “The unequivocal histological hallmark of NAFLD in both adults and children is steatosis, the histologic manifestation of intracytoplasmic lipid in the form of triglycerides (TG) within hepatocytes (29); by definition, steatosis is always a component of NAFLD.”