EPAC null mutation impairs learning and social interactions via aberrant regulation of miR-124 and Zif268 translation

By Ying Yang, Xiaogang Shu, Dan Liu, L. Pei, Lingqiang Zhu, Q. Tian, Jian-Zhi Wang, Youming Lu. Molecular Neurodegeneration, 2012

186 citations recorded by the source corpus.

Result and conclusion We show that EPAC null mutation in the forebrain of mice impairs LTP of synaptic transmission that is paralleled with the abnormal spatial learning and social behaviors. This impairment is mediated in a direct manner by expressing miR-124, which binds to and inhibits Zif268 mRNA translation. Knockdown of miR-124 completely reverses the phenotypes observed in EPAC-/mice, whereas over-expression of miR-124 mimics EPAC null mutation. Thus, miR-124 constitutes a critical epigenetic signaling downstream of EPAC proteins for regulation of learning and social interactions.

View Paper: https://www.semanticscholar.org/paper/ec1e1e04fc3287b9b228844abc8706299b5e09a9