How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions.

By R. Sapolsky, L. M. Romero, A. Munck. Endocrine reviews, 2000

7,674 citations recorded by the source corpus.

Subfields: Behavioral Neuroscience, Endocrinology, Diabetes and Metabolism

View Paper: https://www.semanticscholar.org/paper/ebd72673eacb0559ba50eb5c4868be5409bf1633

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Behavioral Neuroscience

In Endocrinology, Diabetes and Metabolism

Citations in the corpus

Protective and damaging effects of stress mediators: central role of the brain (2006, background): “Whereas catecholamines can increase proinflammatory cytokine production, glucocorticoids are known to inhibit this production.(5) Yet, there are exceptions—proinflammatory effects of glucocorticoids that depend on dose and cell or tissue type.”
Optimal group size and seasonal stress in ring-tailed lemurs (Lemur catta) (2005, background): “Oneofcortisol’sprimarymetabolicfunctionsistodivertenergy from long-term storage for immediate use ( Sapolsky et al., 2000 ).”
Telomeres: Linking stress and survival, ecology and evolution (2010, background): “While the immediate stress response provides significant benefits in the short-term, the stress response may be detrimental and even fatal if activated for the long-term (Sapolsky et al., 2000).”
The Reactive Scope Model - a new model integrating homeostasis, allostasis, and stress. (2009, neutral): “These mediators have been called many things, including homeostatic mediators (Dallman, 2003), allostatic mediators (McEwen, 2003), and even more generically, the stress response (Sapolsky et al., 2000).”
The Biology of the Glucocorticoid Receptor: New Signaling Mechanisms in Health and Disease (2013, background): “Glucocorticoids regulate a plethora of physiological processes including intermediary metabolism, immune function, skeletal growth, cardiovascular function, reproduction, and cognition (1, 2).”
Insights for Behavioral Ecology from Behavioral Syndromes. (2008, background): “For example, the effect of any given hormone, for example corticosteroids, can depend on binding globulins, multiple receptors, receptor densities in different tissues, and interactions and feedbacks among multiple hormones (Sapolsky et al., 2000).”
Social Status and Health in Humans and Other Animals (2004, background): “These two branches typify the double-edged nature of the stress-response, in that glucocorticoids and catecholamines are essential for surviving an acute physical stressor, but are pathogenic when secreted in excess (reviewed in Sapolsky et al. 2000).”
The effects of acute psychological stress on circulating and stimulated inflammatory markers: A systematic review and meta-analysis (2017, background): “It is proposed that these pathways serve an adaptive role, functioning together to regulate peripheral inflammatory responses and promote survival of the organism (Dhabhar, 2009; Dhabhar, 2014; Sapolsky et al., 2000).”
Stress-related and basic determinants of hair cortisol in humans: A meta-analysis. (2016, positive): “3 cortisol reactivity are part of the adaptive response to challenge and generally unharmful (Sapolsky et al., 2000), the cumulative impact of repeated cortisol reactivity and/or long-term dysregulated secretion, e.”