Cellular interactions and signaling in cartilage development.

By A. DeLise, L. Fischer, Rocky S. Tuan. Osteoarthritis and Cartilage, 2000

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Cell-based tissue engineering strategies used in the clinical repair of articular cartilage (2016, background): “Although hydrogels provide a 3D environment, chondrocytes are isolated and devoid of cell-cell interactions, which are critical in chondrogenesis [217] and present during neocartilage formation [195].”
Development of the endochondral skeleton. (2013, background): “Based on expression analyses as well as studies with neutralizing antibodies, N-CAM and N-cadherin, which mediate Ca2+-dependent and -independent cell–cell adhesion, respectively, are implicated in mediating the cell-cell adhesion during condensation (DeLise et al. 2000).”
The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation. (2002, background): “This screen the Pax, Hox, homeodomain-containing, bHLH, and has identified a novel zinc finger-containing transcripForkhead families (Karsenty, 1999; DeLise et al., 2000; tion factor called Osterix (Osx) that is expressed in osOlsen et al., 2000).”
The control of chondrogenesis (2006, background): “Many of the genes that pattern the distribution and proliferation of mesenchymal condensations at sites of future skeletal elements and control subsequent limbdevelopmenthavebeen described [DeLise et al., 2000; Hall andMiyake, 2000; Olsen et al., 2000; Eames et al., 2003] (Fig.”