Frequency of single nucleotide polymorphisms in the P‐glycoprotein drug transporter MDR1 gene in white subjects
By I. Cascorbi, T. Gerloff, A. Johne, C. Meisel, Sven Hoffmeyer, M. Schwab, E. Schaeffeler, M. Eichelbaum, Ulrich Brinkmann, I. Roots. Clinical pharmacology and therapy, 2001
739 citations recorded by the source corpus.
Subfields: Molecular Biology, Oncology, Pharmacology
View Paper: https://www.semanticscholar.org/paper/eb06676e61f25af0dd5d2410db53b1ba200700ae
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Citations in the corpus
- Role of P-Glycoprotein in Pharmacokinetics (2003, background): “G2677A/G2677T polymorphisms with high frequencies in a relatively larger sample population of 461.[62] Similar to the ethnic variation in the polymorphism of CYP,[63] interethnic differences in MDR1 polymorphisms are observed.”
- Polymorphisms in Human MDR1 (P‐glycoprotein): Recent Advances and Clinical Relevance (2004, background): “Subsequently, other groups, including Hoffmeyer et al,(89) have screened the entire MDR1 coding region.(88,90-99) To date, 29 SNPs have been reported in the MDR1 gene.”
- P-glycoprotein: from genomics to mechanism (2003, background): “Interestingly, different variants were found for the location of 2677-Ser893: Cascorbi and associates found the G allele at a frequency of 56.4% (893Ala), the T allele in 41.6% (893Ser), and the A allele (893Thr) in 1.9% of 461 white individuals (Cascorbi et al., 2001).”