Evaluation of tumor microsatellite instability using five quasimonomorphic mononucleotide repeats and pentaplex PCR.

By N. Suraweera, A. Duval, Maryline Répérant, C. Vaury, D. Furlan, K. Leroy, R. Seruca, B. Iacopetta, R. Hamelin. Gastroenterology, 2002

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ESMO recommendations on microsatellite instability testing for immunotherapy in cancer, and its relationship with PD-1/PD-L1 expression and tumour mutational burden: a systematic review-based approach. (2019, methodology): “The pentaplex panel of five poly-A mononucleotide repeats may obviate the need for normal tissue for comparison and may be more sensitive than other microsatellite markers [32, 46, 54].”
Revised Bethesda Guidelines for hereditary nonpolyposis colorectal cancer (Lynch syndrome) and microsatellite instability. (2004, background): “Recently, a single pentaplex polymerase chain reaction (PCR) with five quasimonomorphic mononucleotide repeats was also described (25).”
Review of the Lynch syndrome: history, molecular genetics, screening, differential diagnosis, and medicolegal ramifications (2009, background): “A novel panel of five microsatellite markers has been identified that can be run in a single pentaplex polymerase chain reaction (PCR) that is more sensitive and specific than the original markers, and does not require normal tissue to be analyzed (57).”