Comparison of radiotherapy alone with radiotherapy plus hyperthermia in locally advanced pelvic tumours: a prospective, randomised, multicentre trial

By J. Van der zee, D. González, G. V. van Rhoon, J. V. van Dijk, W. V. van Putten, A. A. Hart. 2000

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Gold nanoparticles as novel agents for cancer therapy. (2012, background): “Hyperthermia is known to induce apoptotic cell death in many tissues and has been shown to increase local control and overall survival in combination with radiotherapy and chemotherapy in randomised clinical trials [32–34].”
Lipid-Based Drug Delivery Systems in Cancer Therapy: What Is Available and What Is Yet to Come (2016, methodology): “This includes implementing: 1) radio frequency heating via an array of antennas (van der Zee et al., 2000) or a catheter (Wood et al., 2012); 2) focused microwaves (Hauck et al., 2006); 3) infrared laser (Salomir et al., 2005); and 4) ultrasound (Deckers et al., 2008; Frenkel, 2008).”
Biomedical Nanomagnetics: A Spin Through Possibilities in Imaging, Diagnostics, and Therapy (2010, positive): “Several clinical studies conducted recently have questioned the need to achieve a minimum temperature of 43 in the target volume and, in fact, effectiveness of hyperthermia at lower temperatures has been reported [204].”
Efficacy and safety of intratumoral thermotherapy using magnetic iron-oxide nanoparticles combined with external beam radiotherapy on patients with recurrent glioblastoma multiforme (2010, background): “The combination of hyperthermia with radiotherapy increases cytotoxic effects, and several clinical trials investigating different techniques in different tumor sites have shown benefits from combined treatment [27–29].”