Macrophages in inflammation, repair and regeneration
By Y. Oishi, I. Manabe. International Immunology, 2018
619 citations recorded by the source corpus.
Tissue injury triggers a complex series of cellular responses, starting from inflammation activated by tissue and cell damage and proceeding to healing. By clearing cell debris, activating and resolving inflammation and promoting fibrosis, macrophages play key roles in most, if not all, phases of the response to injury. Recent studies of the mechanisms underlying the initial inflammation and later tissue regeneration and repair revealed that macrophages bridge these processes in part by supporting and activating stem/progenitor cells, clearing damaged tissue, remodeling extracellular matrix to prepare scaffolding for regeneration and promoting angiogenesis. However, macrophages also have a central role in the development of pathology induced by failed resolution (e.g. chronic inflammation) and excessive scarring. In this review, we summarize the activities of macrophages in inflammation and healing in response to acute injury in tissues with differing regenerative capacities. While macrophages lead similar processes in response to tissue injury in these tissues, their priorities and the consequences of their activities differ among tissues. Moreover, the magnitude, nature and duration of injury also greatly affect cellular responses and healing processes. In particular, continuous injury and/or failed resolution of inflammation leads to chronic ailments in which macrophage activities may become detrimental.
Subfields: Genetics, Immunology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/ea34b1d4a596dbd803ee3ef53efd4670ff3e5b0f
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Immunology
In Molecular Biology
Citations in the corpus
- Macrophage Polarization States in the Tumor Microenvironment (2021, background): “In some genetic diseases such as systemic metabolic dysregulation and muscle dystrophy, the dysfunction of macrophages can lead to worsening conditions such as cancer, atherosclerosis, fibrosis, and other chronic illnesses [8].”