Intestinal barrier function in health and gastrointestinal disease

By Michael Camilleri, K. Madsen, R. Spiller, B. Meerveld, G. Verne. Neurogastroenterology and Motility, 2012

843 citations recorded by the source corpus.

Defects in intestinal barrier function are associated with diseases of the gastrointestinal (GI) tract. There is growing evidence that increases in intestinal permeability plays a pathogenic role in diseases, such as inflammatory bowel disease (IBD) and celiac disease, and functional bowel disorders, such as irritable bowel syndrome (IBS). This review takes a unique translational approach to discuss the physiological and pathophysiological mechanisms involved in the regulation of intestinal barrier function in IBS. The review summarizes the components of the intestinal barrier including the tight junction complex within the epithelium, and the methods used to assess gut permeability both in vitro and in vivo. Throughout the review, the authors have attempted to critically review the latest research from both experimental animal models and human studies to appraise whether intestinal barrier dysfunction is a primary cause of functional GI disorders, such as IBS.…

Subfields: Gastroenterology, Genetics, Physiology

View Paper: https://www.semanticscholar.org/paper/ea02f781f87880d8a4312a59133de7539497fff1

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. Antonio Gasbarrini
2. S. Bischoff
3. Loris Riccardo Lopetuso
4. Herbert Tilg

In Physiology

1. S. Bischoff
2. Herbert Tilg

Citations in the corpus

• Intestinal permeability – a new target for disease prevention and therapy (2014, background): “Some of these pathologies are associated with altered barrier function and increased permeability of the epithelium [6,7].”
• Commensal Clostridia: leading players in the maintenance of gut homeostasis (2013, background): “Dysregulation of any of the aforementioned components have been implicated, not only in the pathogenesis of IBD, but in many other GI disorders, including infectious enterocolitis, IBS, small intestinal bowel overgrowth, celiac sprue, hepatic fibrosis, atopic manifestations and food intolerance [34-”