NF1 tumor suppressor gene function: narrowing the GAP.

By K. Cichowski, T. Jacks. Cell, 2001

611 citations recorded by the source corpus.

Subfields: Molecular Biology, Neurology

View Paper: https://www.semanticscholar.org/paper/e9f902c6dcfa907999c874ef5b7e10602a0cf5e7

How researchers see this paper

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In Molecular Biology

1. J. Brugge
2. A. Alimonti
3. Richard Sever
4. J. Kohli
5. E. Zagato
6. L. Pellegrini
7. A. Calcinotto
8. M. Demaria

Citations in the corpus

• Cellular Senescence: Aging, Cancer, and Injury. (2019, background): “In these lesions, mutations or inactivation of NF1 lead to activation of the N-RAS pathway and to the induction of senescence characterized by high expression of SA- -Gal and p16 (68, 284).”
• Signal transduction in cancer. (2015, background): “The Ras-ERK and PI3K-Akt pathways are important regulators of normal cell proliferation and thus their constitutive hyperactivation can lead to excessive prolifer- RTK Ras Akt PTEN Src Raf Integrin TSC1 TSC2 mTORC1 PI3K Myc ERK Fos-Jun NF1 RSK MSK MNK Other TFs Cell proliferation Cell growth Cell su”