Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis

By G. D’Orazi, Barbara Cecchinelli, T. Bruno, I. Manni, Y. Higashimoto, Shinichi Saito, M. Gostissa, S. Coen, A. Marchetti, G. Sal and 4 more. Nature Cell Biology, 2002

744 citations recorded by the source corpus.

Subfields: Biotechnology, Cancer Research, Oncology

View Paper: https://www.semanticscholar.org/paper/e9d6f708b675f8d5503ab0d2aac6e14e9fe24f30

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In Biotechnology

1. Carol Prives
2. Karen H. Vousden

In Cancer Research

1. Carol Prives
2. Karen H. Vousden

In Oncology

1. Carol Prives
2. Karen H. Vousden
3. T. Ozaki
4. A. Nakagawara
5. Vladimir N Uversky
6. W. Gu

Citations in the corpus

• Blinded by the Light: The Growing Complexity of p53. (2009, background): “In contrast, severe DNA damage results in reduced Mdm2 levels, thus allowing the now stable HIPK2 to phosphorylate p53 at S46 to induce cell death (Rinaldo et al., 2007).”
• Role of p53 in Cell Death and Human Cancers (2011, background): “Among them, phosphorylation of p53 at Ser-46 is closely associated with its pro-apoptotic function.”