Epidemiological studies in incidence, prevalence, mortality, and comorbidity of the rheumatic diseases
By S. Gabriel, K. Michaud. Arthritis Research & Therapy, 2009
907 citations recorded by the source corpus.
Epidemiology is the study of the distribution and determinants of disease in human populations. Over the past decade there has been considerable progress in our understanding of the fundamental descriptive epidemiology (levels of disease frequency: incidence and prevalence, comorbidity, mortality, trends over time, geographic distributions, and clinical characteristics) of the rheumatic diseases. This progress is reviewed for the following major rheumatic diseases: rheumatoid arthritis (RA), juvenile rheumatoid arthritis, psoriatic arthritis, osteoarthritis, systemic lupus erythematosus, giant cell arteritis, polymyalgia rheumatica, gout, Sjögren's syndrome, and ankylosing spondylitis. These findings demonstrate the dynamic nature of the incidence and prevalence of these conditions – a reflection of the impact of genetic and environmental factors. The past decade has also brought new insights regarding the comorbidity associated with rheumatic diseases. Strong evidence now shows that persons with RA are at a high risk for developing several comorbid disorders, that these conditions may have atypical features and thus may be difficult to diagnose, and that persons with RA experience poorer outcomes after comorbidity compared with the general population. Taken together, these findings underscore the complexity of the rheumatic diseases and highlight the key role of epidemiological research in understanding these intriguing conditions.
Subfields: Hematology, Rheumatology
View Paper: https://www.semanticscholar.org/paper/e9c19ece800b64d9b5489947a397212cb98d79fc
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Citations in the corpus
- All cause and disease specific mortality in patients with knee or hip osteoarthritis: population based cohort study (2011, background): “Estimates of the standardised mortality ratio in rheumatoid arthritis vary from about 1.3 to 3.0.”
- Fibroblast-like synoviocytes: key effector cells in rheumatoid arthritis (2010, background): “In addition to disability and decreased quality of life, RA decreases life expectancy, most commonly from accelerated atherosclerosis (1).”