Sugar transporters for intercellular exchange and nutrition of pathogens
By Li‐Qing Chen, B. Hou, S. Lalonde, H. Takanaga, M. L. Hartung, Xiao-Qing Qu, Woei-Jiun Guo, Jung-Gun Kim, William Underwood, B. Chaudhuri and 6 more. Nature, 2010
1,453 citations recorded by the source corpus.
Sugar efflux transporters are essential for the maintenance of animal blood glucose levels, plant nectar production, and plant seed and pollen development. Despite broad biological importance, the identity of sugar efflux transporters has remained elusive. Using optical glucose sensors, we identified a new class of sugar transporters, named SWEETs, and show that at least six out of seventeen Arabidopsis, two out of over twenty rice and two out of seven homologues in Caenorhabditis elegans, and the single copy human protein, mediate glucose transport. Arabidopsis SWEET8 is essential for pollen viability, and the rice homologues SWEET11 and SWEET14 are specifically exploited by bacterial pathogens for virulence by means of direct binding of a bacterial effector to the SWEET promoter. Bacterial symbionts and fungal and bacterial pathogens induce the expression of different SWEET genes, indicating that the sugar efflux function of SWEET transporters is probably targeted by pathogens and symbionts for nutritional gain. The metazoan homologues may be involved in sugar efflux from intestinal, liver, epididymis and mammary cells.
Subfields: Plant Science
View Paper: https://www.semanticscholar.org/paper/e9ac6f9c4635f76ade88c5e714c9cb4eec9c553c
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Citations in the corpus
- Source-to-sink transport of sugar and regulation by environmental factors (2013, background): “SWEETs were at first identified as glucose uniporters but paralogues (i.e., AtSWEET11 and AtSWEET12) can also export sucrose (Chen et al., 2010, 2012).”
- Signaling in Plant-Microbe Interactions (2013, background): “oryzae strain PXO99 having the alternative TAL effector AvrXa7, which activates the another sugar transporter OsSWEET14 for sugar efflux to support the pathogen growth (Chen et al. 2010).”
- Signaling mechanisms in pattern-triggered immunity (PTI). (2015, background): “multiplication (Chen et al., 2010; Wang et al., 2012), production and secretion of antimicrobial compounds including phytoalexins, such as camalexin, and defense-related proteins/peptides,”