Monodisperse Alginate Hydrogel Microbeads for Cell Encapsulation

By Wei-heong Tan, Shoji Takeuchi. 2007

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Continuous generation of hydrogel beads and encapsulation of biological materials using a microfluidic droplet-merging channel (2008, methodology): “Methods utilizing the channel geometry to control the velocity of gel droplet and cross-linker droplet, or internal gelation with cross-linking particles have been developed (Liu et al. 2007; Tan and Takeuchi 2007), but still, the issue of serial coupling of the hydrogel beads with biological assay ”
Porous Polymer Particles - A Comprehensive Guide to Synthesis, Characterization, Functionalization and Applications (2012, methodology): “Soft lithography allows an easy way to manufacture an unlimited number of 2D device designs including T-junction [174], co-flow [153] and flow-focusing [110, 175] geometries (Fig.”
Advances in fabricating spherical alginate hydrogels with controlled particle designs by ionotropic gelation as encapsulation systems (2016, background): “…devices are completely laminar, and the resulting droplets or microbeads have very narrow size distributions with coefficients of variance of less than 5% (Zhang et al., 2006; Capretto, Mazzitelli, Balestra, Tosi, & Nastruzzi, 2008; Huang, Lai, & Lin, 2006; Choi et al., 2007; Tan & Takeuchi, 2007).”