Corticostriatal connectivity and its role in disease
By Gordon M. G. Shepherd. Nature Reviews Neuroscience, 2013
770 citations recorded by the source corpus.
Corticostriatal projections are essential components of forebrain circuits and are widely involved in motivated behaviour. These axonal projections are formed by two distinct classes of cortical neurons, intratelencephalic (IT) and pyramidal tract (PT) neurons. Convergent evidence points to IT versus PT differentiation of the corticostriatal system at all levels of functional organization, from cellular signalling mechanisms to circuit topology. There is also growing evidence for IT/PT imbalance as an aetiological factor in neurodevelopmental, neuropsychiatric and movement disorders — autism, amyotrophic lateral sclerosis, obsessive-compulsive disorder, schizophrenia, Huntington's and Parkinson's diseases and major depression are highlighted here.
Subfields: Cellular and Molecular Neuroscience, Neurology
View Paper: https://www.semanticscholar.org/paper/e977d7137aaab25569287b253ba82be25a723060
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In Cellular and Molecular Neuroscience
In Neurology
Citations in the corpus
- Brain-machine interfaces in neurorehabilitation of stroke. (2015, neutral): “It was shown that these symptoms relate to corticostriatal connectivity (Shepherd, 2013) and disruption of the corticostriatal thalamocortical loop (Terroni et al.”
- Excitatory Cerebellar Nucleocortical Circuit Provides Internal Amplification during Associative Conditioning (2016, neutral): “Cortical and subcortical regions are usually connected by closed-loop circuitries, which are thought to determine the precision of final output patterns (Ahissar and Kleinfeld, 2003; Kelly and Strick, 2003; McCormick et al., 2015; Moser et al., 2008; Shepherd, 2013; Strick et al., 2009).”
- Computational models of basal-ganglia pathway functions: focus on functional neuroanatomy (2013, background): “…of direct and indirect pathways) receives topographically organized inputs both from intratelencephalically-projecting cortical cells and from axon collaterals of cortical pyramidal-tract neurons ( Figure 2A ; Donoghue and Kitai, 1981; Lei et al., 2004; Parent and Parent, 2006; Shepherd, 2013).”