Stimulation of DNA Synthesis Activity of Human DNA Polymerase κ by PCNA

By L. Haracska, I. Unk, Robert E. Johnson, B. Phillips, J. Hurwitz, L. Prakash, S. Prakash. Molecular and Cellular Biology, 2002

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Efficient and Error-Free Replication Past a Minor-Groove DNA Adduct by the Sequential Action of Human DNA Polymerases ι and κ (2004, methodology): “GST-Pol and GST-Pol were expressed in S. cerevisiae strain BJ5464 carrying either plasmid pPOL114 or pPOL42, respectively, as described previously (9, 13 , 17, 18).”
Proliferating cell nuclear antigen (PCNA): a dancer with many partners (2003, background): “…shown that the lesion bypass activity of these enzymes is increased by physical interaction of PCNA (Haracska et al., 2001a; Haracska et al., 2001b; Haracska et al., 2002; Maga et al., 2002), and immunofluorescence studies have shown that pol κ and pol ι accumulate at stalled replication forks…”
Eukaryotic Translesion Polymerases and Their Roles and Regulation in DNA Damage Tolerance (2009, background): “Eukaryotic Pol interacts with the PCNA processivity clamp (human [81]), ubiquitin (mouse [72]), the 9-1-1 checkpoint clamp (S.”