Trade‐offs in evolutionary immunology: just what is the cost of immunity?

By R. Lochmiller, C. Deerenberg. 2000

2,033 citations recorded by the source corpus.

Subfields: Ecology, Ecology, Evolution, Behavior and Systematics, Genetics

View Paper: https://www.semanticscholar.org/paper/e937393e9d4c01bd205f5140c47e13d2796c99a2

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Citations in the corpus

Condition and androgen levels: are condition-dependent and testosterone-mediated traits two sides of the same coin? (2006, background): “Immune response may be affected by body condition as well (Lochmiller & Deerenberg 2000; Alonso-Álvarez & Tella 2001).”
Experimentally induced spermatophore production and immune responses reveal a trade-off in crickets (2010, background): “…occurring between immunity (a vital aspect of bodily maintenance) and other life-history traits, such as growth or reproduction, are of relatively recent interest to behavioral ecologists (Sheldon and Verhulst 1996; Lochmiller and Deerenberg 2000; Zuk and Stoehr 2002; Rantala and Roff 2005).”
Anti-Inflammatory and Immunomodulatory Effects of Probiotics in Gut Inflammation: A Door to the Body (2021, background): “The immune system evolves and operates in an ecosystem that is an integral part of its natural environment (5, 6) and a dramatic shift of this environment, such as that we are experiencing today, may alter a millennial balance of co-evolution causing a mismatch responsible of an increase of a diseas”
Physiological condition and immune function in great tits (Parus major L.): sources of variation and trade-offs in relation to growth (2006, background): “One common factor that links all classes of immune function is that their operation requires resources that the host could use for some other essential functions such as growth, selfmaintenance, reproduction (Sheldon & Verhulst 1996; Norris & Evans 2000; Lochmiller & Deerenberg 2000).”
Immune Defense and Host Life History (2002, background): “Two recent reviews concerning the costs of immunity to vertebrates in general (Lochmiller and Deerenberg 2000) and specifically in birds (Norris and Evans 2000) both concluded that evidence supports the notion that immunity is costly.”
Management of disease in wild mammals (2009, background): “Nutrition influences immune system functioning and hence susceptibility to disease (Lochmillar and Deerenberg 2000; Wobeser 2006).”
Hormones, parasites and male mating tactics in Alpine chamois: identifying the mechanisms of life history trade-offs (2012, background): “…effort, defined as the allocation of energy resources to current reproduction, is traded off against the individual’s ability to defend itself against pathogens (reviewed in Lochmiller & Deerenberg 2000; Zuk & Stoehr 2002; but see the study of Hõrak et al. 2006 on rats, Rattus norvegicus).”
Experimental evidence for physiological costs underlying the trade-off between reproduction and survival. (2010, background): “Because immune function is ener- getically expensive (Demas et al. 1997; Lochmiller & Deeren- berg 2000; Bonneaud et al. 2003; Martin et al. 2003), its characteristic negative association with reproductive invest- ment is thought to reflect underlying energetic trade-offs (Sheldon & Verlhust 1996;…”
Brood size and immunity costs in zebra finches Taeniopygia guttata (2005, background): “Although the metabolic consequences of an immune response were small, the costs could be higher when measured in another currency, e.g. protein or amino acid turnover (Klasing and Austic 1984, Parry Billings et al. 1992, Lochmiller and Deerenberg 2000).”
On the evolutionary ecology of specific immune defence (2003, background): “In both cases, variation in the capacity to defend is explained by appropriate costs (Table 1). In fact, the empirical evidence available collectively indicates that such costs exist and, moreover, can be of significant magnitude [10,12, 13 ].”
Size-mediated dominance and begging behaviour in Eurasian kestrel broods (2003, background): “As the maintenance of immune function against parasites and pathogens is energetically and nutritionally costly ( Lochmiller and Deerenberg, 2000 ), there might also be a trade-off between investment in immune function, begging behaviour or growth (Saino et al., 1997; Horak et al., 1999).”
Global emergence of Batrachochytrium dendrobatidis and amphibian chytridiomycosis in space, time, and host. (2009, background): “Mounting an immune response is costly (14), and how a host regulates an immune response may be as important as the ability to mount an immune response (66).”
Acute phase responses of passerine birds: characterization and seasonal variation (2007, background): “The APR is arguably the most energetically demanding of all immune system defenses (Lochmiller and Deerenberg 2000; Klasing 2004), although much of its costs are attributed to fever, anorexia, and alterations in nutrient use to different organs (Klasing and Austic 1994a, b; Klasing 2004).”