PharmGKB: The Pharmacogenomics Knowledge Base
By Caroline F. Thorn, Teri E. Klein, Russ B. Altman. Methods in molecular biology, 2013
312 citations recorded by the source corpus.
The Pharmacogenomics Knowledge Base, PharmGKB, is an interactive tool for researchers investigating how genetic variation affects drug response. The PharmGKB Web site, http://www.pharmgkb.org, displays genotype, molecular, and clinical knowledge integrated into pathway representations and Very Important Pharmacogene (VIP) summaries with links to additional external resources. Users can search and browse the knowledgebase by genes, variants, drugs, diseases, and pathways. Registration is free to the entire research community, but subject to agreement to use for research purposes only and not to redistribute. Registered users can access and download data to aid in the design of future pharmacogenetics and pharmacogenomics studies.
Subfields: Computational Theory and Mathematics, Oncology, Pharmacology
View Paper: https://www.semanticscholar.org/paper/e92575a720943fd3d1431dc14dfca21074b72460
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Citations in the corpus
- Extracting Drug-Drug Interactions with Attention CNNs (2017, background): “Several drug databases, such as DrugBank (Law et al., 2014), Therapeutic Target Database (Yang et al., 2016), and Phar-mGKB (Thorn et al., 2013), have been provided to summarize drug and DDI information for researchers and professionals; however, many newly discovered or rarely reported interactions”
- Review of Drug Repositioning Approaches and Resources (2018, background): “Pharmacological databases [8, 71-76] are crucial resources for drug repositioning.”
- DrugBank 4.0: shedding new light on drug metabolism (2013, background): “Because most of the data in DrugBank are expertly curated from primary literature sources, it has become the referential drug data source for a number of well-known databases such as PharmGKB (1), ChEBI (2), KEGG (3), GeneCards (4), PDB (5), PubChem (6), UniProt (7) and Wikipedia.”
- The Human Gene Mutation Database: towards a comprehensive repository of inherited mutation data for medical research, genetic diagnosis and next-generation sequencing studies (2017, unknown): “Nor does HGMD attempt to provide comprehensive coverage of pharmacological variants (except for those variants where evidence supporting a functional impairment has been provided); PharmGKB (https://www. pharmgkb.org/; Thorn et al. 2013) is a more comprehensive resource for these data.”
- SMPDB 2.0: Big Improvements to the Small Molecule Pathway Database (2013, background): “Instead, relevant information was gathered from various medical and pharmacology textbooks, specialized encyclopedias and fragmentary data contained on several online databases such as OMIM (13), PharmGKB (6) and DrugBank (9).”
- Understanding multicellular function and disease with human tissue-specific networks (2015, unknown): “Recent advances now allow for high-throughput discovery of genes expressed in specific lineages in solid tissues 9,64 .”