The pathogenesis and treatment of the `Cytokine Storm' in COVID-19

By Q. Ye, Bili Wang, Jian-hua Mao. Journal of Infection, 2020

2,288 citations recorded by the source corpus.

Summary Cytokine storm is a general term applied to maladaptive cytokine release in response to infection and other stimuli. The pathogenesis is complex but includes loss of regulatory control of proinflammatory cytokine production, both at local and systemic levels. The disease progresses rapidly, and the mortality is high. Some evidence shows that, during the coronavirus disease 2019 (COVID-19) epidemic, severe deterioration in some patients has been closely associated with dysregulated and excessive cytokine release. This article reviews what we know of the mechanism and treatment strategies of the COVID-19 virus-induced inflammatory storm in an attempt to provide some background to inform future guidance for clinical treatment.

Subfields: Infectious Diseases, Neurology

View Paper: https://www.semanticscholar.org/paper/e914852d43ea30e092957a6acf64315e5311fa7e

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Citations in the corpus

Exosomes Derived from Bone Marrow Mesenchymal Stem Cells as Treatment for Severe COVID-19 (2020, neutral): “…and other antigen presenting cells, alerting lymphocytes to the presence of the virus, (2) viral RNA replication within host cells, activating synthesis of proin-ﬂammatory factors, and (3) viral invasion of lymphocytes, eliciting lymphocyte apoptosis and facilitating ongoing immune evasion [10,11].”
Anxiety and depression in COVID-19 survivors: Role of inflammatory and clinical predictors (2020, positive): “Moreover, in COVID-19, unlike in SARS and MERS, elevated levels of T-helper-2 cell-secreted cytokines (such as IL-4 and IL-10) were found (Ye et al., 2020; Channappanavar and Perlman, 2017).”