The ratio of blood products transfused affects mortality in patients receiving massive transfusions at a combat support hospital.
By M. Borgman, P. Spinella, J. Perkins, K. Grathwohl, Thomas B. Repine, A. Beekley, J. Sebesta, D. Jenkins, C. Wade, J. Holcomb. Journal of Trauma, 2007
1,537 citations recorded by the source corpus.
Subfields: Biochemistry, Critical Care and Intensive Care Medicine, Hematology
View Paper: https://www.semanticscholar.org/paper/e8f2302ad8bf1cb461a5f0f4e0d2986b7dc72dcf
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In Critical Care and Intensive Care Medicine
In Hematology
Citations in the corpus
- Transfusion of Plasma, Platelets, and Red Blood Cells in a 1:1:1 vs a 1:1:2 Ratio and Mortality in Patients With Severe Trauma (2015, methodology): “Ancillary outcomes were prespecified to evaluate the effectiveness and safety of the transfusion ratios and included (1) time to hemostasis; (2) the number and type of blood products used from randomization until hemostasis was achieved; (3) the number and type of blood products used after hemostasi”
- The Prospective, Observational, Multicenter, Major Trauma Transfusion (PROMMTT) Study: Comparative Effectiveness of a Time-varying Treatment with Competing Risks (2013, neutral): “1) 869 Injury Severity Score 25 (16-34) 1243 26 (17-36) 905 Bleeding site, No.”
- Goal-directed coagulation management of major trauma patients using thromboelastometry (ROTEM®)-guided administration of fibrinogen concentrate and prothrombin complex concentrate (2010, result): “Massive transfusion protocols that favour a red blood cell (RBC):FFP ratio of 1:1 have shown conflicting results [6-14].”
- Management of bleeding and coagulopathy following major trauma: an updated European guideline (2013, background): “In the meantime, 19 studies [135,313,316, 319,345-359], 6 systematic reviews [360-365] and 1 meta-analysis [366] have addressed the impact of FFP:RBC ratio.”
- Management of bleeding following major trauma: an updated European guideline (2010, methodology): “Seven studies showed better outcomes using a high FFP:RBC ratio [3,261-266] and two did not [250,267].”
- The coagulopathy of trauma: a review of mechanisms. (2008, background): “One approach that shows promise in a retrospective study is the early administration of high-dose fresh frozen plasma to massively transfused trauma patients.(19) Further prospective studies are required to investigate this approach and the role of platelet transfusion and therapeutic agents such as”