Visible-Light-Triggered Reactive-Oxygen-Species-Mediated Antibacterial Activity of Peroxidase-Mimic CuO Nanorods

By M. N. Karim, Mandeep Singh, Pabudi Weerathunge, Pengju Bian, R. Zheng, Chaitali Dekiwadia, Taimur Ahmed, S. Walia, E. D. Gaspera, Sanjay Singh and 2 more. 2018

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The rapid emergence of antibiotic-resistant bacterial strains warrants new strategies for infection control. NanoZymes are emerging as a new class of catalytic nanomaterials that mimic the biological action of natural enzymes. The development of photoactive NanoZymes offers a promising avenue to use light as a “trigger” to modulate the bacterial activity. Visible light activity is particularly desirable because it contributes to 44% of the total solar energy. Here we show that the favorable band structure of a CuO-nanorod-based NanoZyme catalyst (band gap of 1.44 eV) allows visible light to control the antibacterial activity. Photomodulation of the peroxidase-mimic activity of CuO nanorods enhances its affinity to H2O2, thereby remarkably accelerating the production of reactive oxygen species (ROS) by 20 times. This photoinduced NanoZyme-mediated ROS production catalyzes physical damage to the bacterial cells, thereby enhancing the antibacterial performance against Gram-negative-indicator bacteria Escheri...

Subfields: Materials Chemistry

View Paper: https://www.semanticscholar.org/paper/e8878dfb30a5192859d267d57aa8c98509174734