Multidrug efflux pumps: structure, function and regulation

By D. Du, Wang-Kan Xuan, A. Neuberger, H. V. van Veen, K. M. Pos, L. Piddock, B. Luisi. Nature Reviews Microbiology, 2018

881 citations recorded by the source corpus.

Subfields: Molecular Biology, Molecular Medicine, Pharmacology

View Paper: https://www.semanticscholar.org/paper/e867b8a4e737bc37c22c69236744883605b50b86

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Citations in the corpus

• Biofilms as Promoters of Bacterial Antibiotic Resistance and Tolerance (2020, background): “These families display large differences concerning transporter structure, function, and substrate specificity and energy source [123].”
• Molecular mechanisms of antibiotic resistance revisited (2022, background): “In the presence of substrates, such as puromycin, the periplasmic tip of the OMF TolC is dilated, while the three protomers of the RND transporter AcrB assume an asymmetric conformation — loose, tight and open — presumably in preparation for drug efflux(34) (for a graphical representation see ref.(3”