Effect of procalcitonin-guided treatment on antibiotic use and outcome in lower respiratory tract infections: cluster-randomised, single-blinded intervention trial.

By M. Christ-Crain, Daiana Jaccard-Stolz, R. Bingisser, M. Gencay, P. Huber, M. Tamm, B. Müller. The Lancet, 2004

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Procalcitonin guidance of antibiotic therapy in community-acquired pneumonia: a randomized trial. (2006, methodology): “As a diagnostic marker, procalcitonin guidance markedly and safely reduced antibiotic prescriptions in a mixed population with lower respiratory tract infections, using a sensitive assay (13).”
Use of procalcitonin to shorten antibiotic treatment duration in septic patients: a randomized trial. (2008, methodology): “PCT has been used to guide the initiation of antibiotic treatment in patients presenting in the emergency department with respiratory infection (9).”
Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. (2007, background): “Procalcitonin III, a marker that is specific for bacterial infections, may be of value in the decision to use antibiotics (140), but this test is expensive and thus not widely established.”