A Prospective Study of Obstructive Sleep Apnea and Incident Coronary Heart Disease and Heart Failure: The Sleep Heart Health Study
By Daniel J. Gottlieb, G. Yenokyan, A. Newman, George T. O'Connor, Naresh M. Punjabi, Stuart F. Quan, S. Redline, Helaine E. Resnick, E. Tong, Marie Diener-West and 1 more. Circulation, 2010
1,502 citations recorded by the source corpus.
Background— Clinic-based observational studies in men have reported that obstructive sleep apnea is associated with an increased incidence of coronary heart disease. The objective of this study was to assess the relation of obstructive sleep apnea to incident coronary heart disease and heart failure in a general community sample of adult men and women. Methods and Results— A total of 1927 men and 2495 women ≥40 years of age and free of coronary heart disease and heart failure at the time of baseline polysomnography were followed up for a median of 8.7 years in this prospective longitudinal epidemiological study. After adjustment for multiple risk factors, obstructive sleep apnea was a significant predictor of incident coronary heart disease (myocardial infarction, revascularization procedure, or coronary heart disease death) only in men ≤70 years of age (adjusted hazard ratio 1.10 [95% confidence interval 1.00 to 1.21] per 10-unit increase in apnea-hypopnea index [AHI]) but not in older men or in women of any age. Among men 40 to 70 years old, those with AHI ≥30 were 68% more likely to develop coronary heart disease than those with AHI <5. Obstructive sleep apnea predicted incident heart failure in men but not in women (adjusted hazard ratio 1.13 [95% confidence interval 1.02 to 1.26] per 10-unit increase in AHI). Men with AHI ≥30 were 58% more likely to develop heart failure than those with AHI <5. Conclusions— Obstructive sleep apnea is associated with an increased risk of incident heart failure in community-dwelling middle-aged and older men; its association with incident coronary heart disease in this sample is equivocal.
Subfields: Cardiology and Cardiovascular Medicine, Physiology, Pulmonary and Respiratory Medicine
View Paper: https://www.semanticscholar.org/paper/e850fc7004657447db67a11c267d2d2fa7ce6427
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In Pulmonary and Respiratory Medicine
Citations in the corpus
- Obstructive sleep apnea: a cardiometabolic risk in obesity and the metabolic syndrome. (2013, background): “11 • Heart remodeling and arrhythmias Recent evidence indicates that OSA is independently associated with incident heart failure (66).”
- European Guidelines on Cardiovascular Disease Prevention in Clinical Practice (Version 2012) (2012, neutral): “The risk correlates in men between 40 and 70 years with the apnoea–hypopnea index.(167) Screening for and treating OSA in patients with chronic coronary artery disease(178) and hypertension may result in decreased cardiac events and cardiac death.”
- 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure (2016, neutral): “OSA is associated with an increased risk of incident HF in men.(487)”
- Increased prevalence of sleep-disordered breathing in adults. (2013, background): “The estimated increases translate to millions of additional afflicted persons in the United States, and, consequently, incidences of sequelae of SDB, such as cardiovascular morbidities and stroke (1, 33, 34), cognitive decline (4), depression (7), and premature death (8, 9), are likely accelerated r”