Diabetes increases the risk of chronic liver disease and hepatocellular carcinoma.
By H. B. EL‐SERAG, T. Tran, J. Everhart. Gastroenterology, 2004
1,228 citations recorded by the source corpus.
BACKGROUND & AIMS An association between diabetes and chronic liver disease has been reported. However, the temporal relationship between these conditions remains unknown. METHODS We identified all patients with a hospital discharge diagnosis of diabetes between 1985 and 1990 using the computerized records of the Department of Veterans Affairs. We randomly assigned 3 patients without diabetes for every patient with diabetes. We excluded patients with concomitant liver disease. The remaining cohort was followed through 2000 for the occurrence of chronic nonalcoholic liver disease (CNLD) and hepatocellular carcinoma (HCC). Hazard rate ratios (HRR) were determined in Cox proportional hazard survival analysis. RESULTS The study cohort comprised 173,643 patients with diabetes and 650,620 patients without diabetes. Most were men (98%). Patients with diabetes were older (62 vs. 54 years) than patients without diabetes. The incidence of chronic nonalcoholic liver disease was significantly higher among patients with diabetes (incidence rate: 18.13 vs. 9.55 per 10,000 person-years, respectively, P < 0.0001). Similar results were obtained for HCC (incidence rate: 2.39 vs. 0.87 per 10,000 person-years, respectively, P < 0.0001). Diabetes was associated with an HRR of 1.98 (95% CI: 1.88 to 2.09, P < 0.0001) of CNLD and an HRR of 2.16 (1.86 to 2.52, P < 0.0001) of hepatocellular carcinoma. Diabetes carried the highest risk among patients with longer than 10 years of follow-up. CONCLUSIONS Among men with diabetes, the risk of CNLD and HCC is doubled. This increase in risk is independent of alcoholic liver disease, viral hepatitis, or demographic features.
Subfields: Endocrinology, Diabetes and Metabolism, Epidemiology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/e81b8843537221b6747ac889fda6690c2e1f30ae
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Endocrinology, Diabetes and Metabolism
In Epidemiology
In Molecular Biology
Citations in the corpus
- Nonalcoholic fatty liver disease and hepatocellular carcinoma: A weighty connection (2010, background): “In a larger longitudinal study, the same group compared 173,643 diabetic patients with 650,620 nondiabetic controls over 10-15 years.(71) The incidence of HCC increased more than two-fold among diabetic patients with higher increase among those with longer duration of follow-up.”
- Standards of Medical Care in Diabetes—2014 (2013, background): “In a prospective analysis, diabetes was significantly associated with incident nonalcoholic chronic liver disease and with hepatocellular carcinoma (482).”
- NF-κB in the liver—linking injury, fibrosis and hepatocellular carcinoma (2011, background): “Moreover, the presence of diabetes nearly doubles the risk for HCC”