α-ketoglutarate orchestrates macrophage activation through metabolic and epigenetic reprogramming
By Pu-Ste Liu, Haiping Wang, Xiaoyun Li, T. Chao, Tony Teav, S. Christen, Giusy Di Conza, Wan-Chen Cheng, Chih-Hung Chou, Magdalena Vavakova and 7 more. Nature Immunology, 2017
1,098 citations recorded by the source corpus.
Subfields: Immunology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/e80dba2d1ae6e72ecba6dc568e3355ab5be6d9aa
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In Immunology
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- A. Viola
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- David S. Wishart
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In Molecular Biology
- Ping Gao
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- Huafeng Zhang
- Linchong Sun
- Jianguo Xia
- Jasmine Chong
- Beomsoo Han
Citations in the corpus
- The Metabolic Signature of Macrophage Responses (2019, background): “On the other hand, glutamine metabolism drives M2 polarization by acting at multiple levels: (i) α-ketoglutarate generated from glutaminolysis is essential for M2 OXPHOS and FAO; (ii) αketoglutarate generated from glutaminolysis promotes an M2 phenotype by macrophage epigenetic reprogramming, involv”
- Metabolic reprogramming and epigenetic modifications on the path to cancer (2021, background): “H3K27 methyltransferase EZH2 is the catalytic component of PRC2, an established transcriptional repressor (Cao et al., 2002; Levine et al., 2004).”
- Metabolomics for Investigating Physiological and Pathophysiological Processes. (2019, background): “This has led to a number of targeted metabolomic studies aimed at identifying previously unsuspected roles for these organic acid hormones in thermogenesis (325), macrophage activation (282), T cell proliferation (63), ischemic injury (85), and obesity (525).”
- Macrophage Polarization: Different Gene Signatures in M1(LPS+) vs. Classically and M2(LPS–) vs. Alternatively Activated Macrophages (2019, background): “The Glutamine synthetase (Glul) is a gene associated with glutamine metabolism, an essential pathway for the differentiation and function of macrophages (56).”