Distinct Cerebellar Contributions to Intrinsic Connectivity Networks

By Christophe Habas, Nirav V Kamdar, D. Nguyen, Katherine E. Prater, Christian F. Beckmann, Vinod Menon, Michael D. Greicius. Journal of Neuroscience, 2009

1,043 citations recorded by the source corpus.

Convergent data from various scientific approaches strongly implicate cerebellar systems in nonmotor functions. The functional anatomy of these systems has been pieced together from disparate sources, such as animal studies, lesion studies in humans, and structural and functional imaging studies in humans. To better define this distinct functional anatomy, in the current study we delineate the role of the cerebellum in several nonmotor systems simultaneously and in the same subjects using resting state functional connectivity MRI. Independent component analysis was applied to resting state data from two independent datasets to identify common cerebellar contributions to several previously identified intrinsic connectivity networks (ICNs) involved in executive control, episodic memory/self-reflection, salience detection, and sensorimotor function. We found distinct cerebellar contributions to each of these ICNs. The neocerebellum participates in (1) the right and left executive control networks (especially crus I and II), (2) the salience network (lobule VI), and (3) the default-mode network (lobule IX). Little to no overlap was detected between these cerebellar regions and the sensorimotor cerebellum (lobules V–VI). Clusters were also located in pontine and dentate nuclei, prominent points of convergence for cerebellar input and output, respectively. The results suggest that the most phylogenetically recent part of the cerebellum, particularly crus I and II, make contributions to parallel cortico-cerebellar loops involved in executive control, salience detection, and episodic memory/self-reflection. The largest portions of the neocerebellum take part in the executive control network implicated in higher cognitive functions such as working memory.

Subfields: Cognitive Neuroscience, Neurology

View Paper: https://www.semanticscholar.org/paper/e7e3963c85206c729d26bd98a51c904c74db1dbc

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Citations in the corpus

The cerebellum and cognitive function: 25 years of insight from anatomy and neuroimaging. (2013, background): “Three independent studies examining coupling with cerebral association cortex, including prefrontal regions, all demonstrated that extensive portions of the cerebellum map to association cortex (Habas et al., 2009; Krienen and Buckner, 2009; O’Reilly et al., 2010).”
Cerebellar networks with the cerebral cortex and basal ganglia. (2013, methodology): “The available experiments, using resting state imaging to establish functional connectivity (fcMRI), report that the human dentate is connected with both motor and non-motor networks of the cerebral cortex [32, 33].”
Consensus Paper: The Cerebellum's Role in Movement and Cognition (2013, background): “1), functional imaging investigations [51] and resting state functional connectivity mapping studies in humans [43, 52, 53], and from clinical studies in patients [54–57].”
Identifying major depression using whole-brain functional connectivity: a multivariate pattern analysis. (2012, background): “The cerebellum may contribute to certain non-motor functions, including emotion and cognitive processing (Dolan, 1998; Schmahmann and Sherman, 1998; Schmahmann and Caplan, 2006; Hu et al., 2008; Habas et al., 2009; Krienen and Buckner, 2009; O’Reilly et al., 2010; Moulton et al., 2011).”
Decreased Functional Connectivity by Aging Is Associated with Cognitive Decline (2012, neutral): “Since then, a number of studies have confirmed the salience network using seed-based analyses (Li, Qin, Zhang, Jiang, & Yu, 2012; Woodward, Rogers, & Heckers, 2011) and ICA (Thomason, Hamilton, & Gotlib, 2011; Weissman-Fogel, Moayedi, Taylor, Pope, & Davis, 2010; Habas et al., 2009).”
Functional topography of the cerebellum for motor and cognitive tasks: an fMRI study (2011, background): “These findings also correspond with resting-state functional connectivity studies which show that activity in sensorimotor cortices correlates with activity in cerebellar lobules V, VI and VIII (Habas et al., 2009; Krienen and Buckner, 2009; O'Reilly et al., 2010).”
Pitch discrimination in cerebellar patients: evidence for a sensory deficit. (2009, neutral): “These ideas have been supported specifically by findings from human functional neuroimaging and neurology, with implications for functional topology (see, e.g., Riva and Giorgi, 2000; Steinlin et al., 2003; Exner et al., 2004; Tavano et al., 2007; Baillieux et al., 2008; Habas et al., 2009).”
Advances and Pitfalls in the Analysis and Interpretation of Resting-State FMRI Data (2010, neutral): “RSNs display reliable and consistent functional connectivity patterns with specifi c thalamic (Zhang et al., 2008) and cerebellar nuclei (Habas et al., 2009; Krienen and Buckner, 2009; O’Reilly et al., 2009).”
TRIPLE REPRESENTATION OF LANGUAGE, WORKING MEMORY, SOCIAL AND EMOTION PROCESSING IN THE CEREBELLUM: CONVERGENT EVIDENCE FROM TASK AND SEED-BASED RESTING-STATE FMRI ANALYSES IN A SINGLE LARGE COHORT (2018, background): “, 2012); as well as default-mode network representation in lobule IX (Habas et al., 2009; Krienen and Buckner, 2009; O'Reilly et al., 2010; Buckner et al., 2011) and representation of dorsal attention and frontoparietal networks in lobule X (Buckner et al.”
The Cerebellum and Cognition: Evidence from Functional Imaging Studies (2011, background): “I and Crus II), the “salience network” (lobule VI), and the default network (lobule IX [19]).”
Consensus Paper: Roles of the Cerebellum in Motor Control—The Diversity of Ideas on Cerebellar Involvement in Movement (2011, background): “cerebellar cortex [256].”