Molecular Evolution of Zika Virus during Its Emergence in the 20th Century
By O. Faye, C. C. M. Freire, Atila Iamarino, O. Faye, Juliana Velasco C. de Oliveira, M. Diallo, P. Zanotto, A. Sall. PLoS Neglected Tropical Diseases, 2014
796 citations recorded by the source corpus.
Zika virus (ZIKV) is a mosquito-borne flavivirus first isolated in Uganda in 1947. Although entomological and virologic surveillance have reported ZIKV enzootic activity in diverse countries of Africa and Asia, few human cases were reported until 2007, when a Zika fever epidemic took place in Micronesia. In the context of West Africa, the WHO Collaborating Centre for Arboviruses and Hemorrhagic Fever at Institut Pasteur of Dakar (http://www.pasteur.fr/recherche/banques/CRORA/) reports the periodic circulation of ZIKV since 1968. Despite several reports on ZIKV, the genetic relationships among viral strains from West Africa remain poorly understood. To evaluate the viral spread and its molecular epidemiology, we investigated 37 ZIKV isolates collected from 1968 to 2002 in six localities in Senegal and Côte d'Ivoire. In addition, we included strains from six other countries. Our results suggested that these two countries in West Africa experienced at least two independent introductions of ZIKV during the 20th century, and that apparently these viral lineages were not restricted by mosquito vector species. Moreover, we present evidence that ZIKV has possibly undergone recombination in nature and that a loss of the N154 glycosylation site in the envelope protein was a possible adaptive response to the Aedes dalzieli vector.
View Paper: https://www.semanticscholar.org/paper/e79723bb679f587a1f63c98629547f5723ef5694
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Citations in the corpus
- Zika Virus, French Polynesia, South Pacific, 2013 (2014, result): “The phylogenetic tree shows that the ZIKV that recently emerged in French Polynesia is similar to Cambodia 2010 and Yap State 2007 strains, which corroborates previous findings of an expansion of ZIKV Asian lineage (7,8).”
- Zika virus: History, emergence, biology, and prospects for control. (2016, background): “Zika virus (ZIKV) was discovered in the Zika Forest of Uganda during research supported by the Rockefeller Foundation to study the enzootic or sylvatic cycle of yellow fever virus and to identify additional arboviruses.”
- First report of autochthonous transmission of Zika virus in Brazil (2015, background): “The virus belongs to the genus Flavivirus, family Flaviviridae, and is closely related to other flaviviruses of public health relevance including dengue (DENV), yellow fever and West Nile viruses (Pierson & Diamond 2013, Faye et al. 2014).”