The molecular architecture of the TNF superfamily.

By J. Bodmer, P. Schneider, J. Tschopp. TIBS -Trends in Biochemical Sciences. Regular ed, 2002

947 citations recorded by the source corpus.

Subfields: Immunology, Immunology and Allergy, Oncology

View Paper: https://www.semanticscholar.org/paper/e79263b5b5ec77442cc1a2e17706ddef20ec541d

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. M. Croft
2. F. Mackay
3. A. Clark
4. Ivan Dikic
5. K. Murphy
6. M. Malcangio
7. E. Old

In Oncology

1. Tony Pawson
2. Ivan Dikic
3. K. Murphy

Citations in the corpus

• Co-stimulatory members of the TNFR family: keys to effective T-cell immunity? (2003, background): “OX40 (CD134), 4-1BB (CD137), CD27, CD30 and HVEM are type I transmembrane proteins that have in common several extracellular cysteine-rich domains, which typically consist of pseudo-repeats of six cysteines that form three disulphide bridge”
• B and T lymphocyte attenuator regulates T cell activation through interaction with herpesvirus entry mediator (2005, background): “We are not aware of any other examples of a known TNFR family member's being the ligand for an immunoglobulin superfamily recepto”
• Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes. (2003, neutral): “…(DR4), TRAIL-R2 (DR5), DR6 and EDAR) share not only the typical amino-terminal cysteine-rich domains (CRDs), which define their ligand specificity (Bodmer et al., 2002), but also a stretch of 60-70 amino acids called the death domain (DD) that is necessary for the induction of apoptosis…”
• The role of glia in the spinal cord in neuropathic and inflammatory pain. (2015, background): “The TNF receptors are the other members of this family of proteins; two have been identified and are either constitutively expressed (TNFR1/p55-R) or inducible (TNFR2/p75-R) (Bodmer et al. 2002; Leung and Cahill 2010).”
• Post-translational modifications in signal integration (2010, background): “Signaling through TNFR TNFα and TNFR1 belong to the large superfamilies of trimeric cytokines and trimeric receptors, respectivel”
• The Role of Inflammatory and Anti-Inflammatory Cytokines in the Pathogenesis of Osteoarthritis (2014, background): “It is one of the 19 ligands within the tumour necrosis factors superfamily (TNF superfamily) [48].”
• BAFF: A fundamental survival factor for B cells (2002, background): “cgi?l=1896">EDA (ectodysplasin A), and the structural features of this subfamily of potential survival factors are intriguin”