Structure and interactions in chitosan hydrogels formed by complexation or aggregation for biomedical applications.

By J. Berger, M. Reist, J. Mayer, O. Felt, R. Gurny. European journal of pharmaceutics and biopharmaceutics, 2004

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Radiation-grafted copolymers for separation and purification purposes: Status, challenges and future directions (2012, background): “On the other hand, crosslinking causes the formation of network structure among chitosan molecular chains to boost the mechanical stability of the biosorbent materials [367].”
Functional Characterization of Chitin and Chitosan (2009, background): “However, the DD was pointed to as another factor that may be involved in the chelation ability of chitosans [108-181].”
Recent developments in polysaccharide-based materials used as adsorbents in wastewater treatment (2005, neutral): “[77] Berger J, Reist M, Mayer JM, Felt O, Peppas NA, Gurny R.”
Chitosan-based hydrogels for controlled, localized drug delivery. (2010, background): “These polymer mixtures form junction points in the form of crystallites and interpolymer complexation after lyophilization or after a series of freeze–thaw cycles [57,68].”
In situ forming implants - an attractive formulation principle for parenteral depot formulations. (2012, background): “However without further chemical crosslinking the gels possess low mechanical stability and rapid release of low molecular weight drugs [18,33].”
Chitosan: A Natural Biopolymer with a Wide and Varied Range of Applications (2020, background): “It has been reported that glutaraldehyde-crosslinked chitosan-gelation is pH-sensitive to drug delivery since this gel can swells and de-swells in a wider range of pH [94].”