Confirmation of functional zones within the human subthalamic nucleus: Patterns of connectivity and sub-parcellation using diffusion weighted imaging
By Christian Lambert, Ludvic U. Zrinzo, Zoltán Nagy, Antoine Lutti, Marwan I. Hariz, T. Foltynie, Bogdan Draganski, John Ashburner, Richard S. J. Frackowiak. NeuroImage, 2012
330 citations recorded by the source corpus.
The subthalamic nucleus (STN) is a small, glutamatergic nucleus situated in the diencephalon. A critical component of normal motor function, it has become a key target for deep brain stimulation in the treatment of Parkinson's disease. Animal studies have demonstrated the existence of three functional sub-zones but these have never been shown conclusively in humans. In this work, a data driven method with diffusion weighted imaging demonstrated that three distinct clusters exist within the human STN based on brain connectivity profiles. The STN was successfully sub-parcellated into these regions, demonstrating good correspondence with that described in the animal literature. The local connectivity of each sub-region supported the hypothesis of bilateral limbic, associative and motor regions occupying the anterior, mid and posterior portions of the nucleus respectively. This study is the first to achieve in-vivo, non-invasive anatomical parcellation of the human STN into three anatomical zones within normal diagnostic scan times, which has important future implications for deep brain stimulation surgery.
Subfields: Neurology, Radiology, Nuclear Medicine and Imaging
View Paper: https://www.semanticscholar.org/paper/e75bb20c8a8bb1e1adfb79659c36e2d1b623cc42
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Citations in the corpus
- Toward defining deep brain stimulation targets in MNI space: A subcortical atlas based on multimodal MRI, histology and structural connectivity (2016, methodology): “6; Accolla et al., 2014, Lambert et al., 2012).”
- Using high-resolution quantitative mapping of R1 as an index of cortical myelination (2014, neutral): “MPM acquisitions offer interesting prospects for the multivariate study of the brain's morphology (Helms et al., 2009; Lambert et al., 2012) and micro-architecture (Draganski et al., 2011).”
- Lead-DBS: A toolbox for deep brain stimulation electrode localizations and visualizations (2015, positive): “As shown in Accolla et al. (2014), Castrioto et al. (2014), and Lambert et al. (2012), the STN can further be subdivided into functional zones that may be used best for postsurgical evaluation if they prevail in a standardized space.”