Pathophysiology of traumatic brain injury.

By C. Werner, K. Engelhard. British Journal of Anaesthesia, 2007

2,008 citations recorded by the source corpus.

The knowledge of the pathophysiology after traumatic head injury is necessary for adequate and patient-oriented treatment. As the primary insult, which represents the direct mechanical damage, cannot be therapeutically influenced, target of the treatment is the limitation of the secondary damage (delayed non-mechanical damage). It is influenced by changes in cerebral blood flow (hypo- and hyperperfusion), impairment of cerebrovascular autoregulation, cerebral metabolic dysfunction and inadequate cerebral oxygenation. Furthermore, excitotoxic cell damage and inflammation may lead to apoptotic and necrotic cell death. Understanding the multidimensional cascade of secondary brain injury offers differentiated therapeutic options.

Subfields: Molecular Biology, Neurology

View Paper: https://www.semanticscholar.org/paper/e7027a4f6027721b8bf6a7fa067cd13f84b36838

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In Molecular Biology

1. Tristan Naumann
2. Peter Szolovits
3. Marzyeh Ghassemi
4. Yuan Luo

Citations in the corpus

• A Multivariate Timeseries Modeling Approach to Severity of Illness Assessment and Forecasting in ICU with Sparse, Heterogeneous Clinical Data (2015, background): “Cerebrovascular autoregulation is an important mechanism to sustain adequate cerebral blood flow (Werner and Engelhard 2007), and impairment of this mechanism indicates an increased risk to secondary brain damage and mortality (Hlatky, Valadka, and Robertson 2005).”