The Tumour Microenvironment after Radiotherapy: Mechanisms of Resistance and Recurrence
By H. Barker, J. Paget, A. Khan, Kevin J. Harrington. Nature Reviews. Cancer, 2015
1,909 citations recorded by the source corpus.
Radiotherapy plays a central part in curing cancer. For decades, most research on improving treatment outcomes has focused on modulating radiation-induced biological effects on cancer cells. Recently, we have better understood that components within the tumour microenvironment have pivotal roles in determining treatment outcomes. In this Review, we describe vascular, stromal and immunological changes that are induced in the tumour microenvironment by irradiation and discuss how these changes may promote radioresistance and tumour recurrence. We also highlight how this knowledge is guiding the development of new treatment paradigms in which biologically targeted agents will be combined with radiotherapy.
Subfields: Cancer Research, Molecular Biology, Psychiatry and Mental health
View Paper: https://www.semanticscholar.org/paper/e6bd2b3c25654368f15af3d2225a7406553f33a2
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In Cancer Research
In Molecular Biology
Citations in the corpus
- Tumor Targeting via EPR: Strategies to Enhance Patient Responses (2018, background): “Ionizing radiation has an effect on a variety of different cell types within the TME, and besides increasing vascular leakiness, it can also induce therapy resistance and metastasis [107,108].”
- A Comprehensive Review on MAPK: A Promising Therapeutic Target in Cancer (2019, background): “Moreover, ECM regulates intercellular communication, cell junction plasticity, and cell adhesion molecules that interact with a wide range of cytokines/chemokine or growth factors [5,69,72,73].”