Human neutralizing antibodies elicited by SARS-CoV-2 infection

By B. Ju, Qi Zhang, J. Ge, Ruoke Wang, Jing Sun, X. Ge, Jiazheng Yu, S. Shan, Bingjie Zhou, Shuo Song and 14 more. Nature, 2020

1,575 citations recorded by the source corpus.

Subfields: Animal Science and Zoology, Infectious Diseases

View Paper: https://www.semanticscholar.org/paper/e68c93d2d749a5133a83f2a4995ca3365568b790

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Animal Science and Zoology

1. F. Krammer
2. F. Amanat

In Infectious Diseases

1. F. Krammer
2. F. Amanat
3. Wenshuai Wang
4. Anna Marie Pyle

Citations in the corpus

• COVID-19: angiotensin-converting enzyme 2 (ACE2) expression and tissue susceptibility to SARS-CoV-2 infection (2021, background): “ACE2 is a surrogate for virus neutralization [134].”
• Structures of Human Antibodies Bound to SARS-CoV-2 Spike Reveal Common Epitopes and Recurrent Features of Antibodies (2020, neutral): “Other studies have also reported anti-SARS-CoV-2 mAbs derived from these genes (Brouwer et al., 2020; Cao et al., 2020; Chi et al., 2020; Ju et al., 2020; Rogers et al., 2020; Seydoux et al., 2020; Wu et al., 2020c; Zost et al., 2020).”
• A Potently Neutralizing Antibody Protects Mice against SARS-CoV-2 Infection (2020, result): “Consistent with a recent report (52), none of”
• Complete mapping of mutations to the SARS-CoV-2 spike receptor-binding domain that escape antibody recognition (2020, neutral): “…studies showing that potent anti-RBD neutralizing antibodies often strongly compete with ACE2 binding (Brouwer et al., 2020; Cao et al., 2020; Huang et al., 2020; Ju et al., 2020; Liu et al., 2020; Rogers et al., 2020; Seydoux et al., 2020; Wec et al., 2020; Wu et al., 2020; Zost et al., 2020a) .”
• Deep mutational scanning of SARS-CoV-2 receptor binding domain reveals constraints on folding and ACE2 binding (2020, neutral): “The RBD is the dominant target of neutralizing antibodies (Cao et al., 2020; Ju et al., 2020; Pinto et al., 2020; Rogers et al., 2020; Seydoux et al., 2020; Shi et al., 2020; Wu et al., 2020; Zost et al., 2020), and so any antigenic drift will be constrained by its mutational tolerance.”
• The Impact of Mutations in SARS-CoV-2 Spike on Viral Infectivity and Antigenicity (2020, positive): “Specifically, P2B-2F6 and P2C-1F11 were obtained using RBD as a bait to isolate RBD-specific B cells in peripheral blood mononuclear cells (PBMCs) of SARS-CoV-2 patients (Ju et al., 2020).”
• mRNA-based COVID-19 vaccine boosters induce neutralizing immunity against SARS-CoV-2 Omicron variant (2021, neutral): “Limitations of the study Although previous studies that used pseudovirus neutralization tomodel the sensitivity of replicating SARS-CoV-2 to neutralizing antibodies have shown excellent correlations (Crawford et al., 2020; Ju et al., 2020;Moore et al., 2004; Pinto et al., 2020; Riepler et al., 2020;”
• Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity (2021, neutral): “Vaccine-elicited neutralizing responses to circulating SARS-CoV-2 strains We accrued a cohort of 99 individuals who received either one or two full doses of the BNT162b2 or mRNA-1273 vaccines and used a luminescence-based lentiviral pseudovirus neutralization assay that we and others have previously”